1. 基本情况：
喻华，博士，副教授，硕士生导师，于南京大学生物科学系获学士学位，因专业成绩优异，保送至中国科学院上海生化与细胞研究所硕博连读。曾作为中科院优秀学生干部代表，与诺贝尔奖得主詹姆斯·沃森交流；喻华副教授的工作亦曾得到美国科学院院士、干细胞与癌症生物领域大师Hans Clevers教授的亲切指导。先后于中科院上海生化与细胞研究所、我校进行博士后深造。2021年10月任best365体育官网入口平台副教授至今。
2. 科研：
长期从事腹部肿瘤的代谢重塑与耐药，代谢产物调控的信号转导等方面的研究，在肿瘤代谢领域取得较丰硕的研究成果。
在该领域以第一作者或通讯作者（含共同）身份在《Nature Communications》，《Hepatology》，《Cell Research》，《Cellular and Molecular Immunology》，《Advanced Science》，《Journal of Clinical Investigation》，《The EMBO Journal》（三篇）和《Cell Death and Differentiation》（两篇）等权威中科院一区期刊发表SCI论文13篇，当年影响因子都>10；以第二作者身份在《Nature》和《Molecular Cell》等顶级期刊发表论文。以上论文均为申请人在国内坚持自主科研的前提下获得的成果，总影响因子逾300，他引次数近1000。
3.重要科研项目清单
（1） 国家自然科学基金，青年科学基金项目
（2） 广东省自然科学基金面上项目
（3） 中国博士后科学基金（两次）。
4.发表代表性论文
近五年在肿瘤代谢、肿瘤免疫、信号转导、表观遗传及多学科交叉方向的代表性论文（权威期刊，篇均当年IF>10）
1) Shao J, Shi T, Chen L, Wang X, Yu H (共同通讯), Feng N and Wang X. AF9 targets acetyl-modified STAT6 to diminish purine metabolism and accelerate cell apoptosis during metastasis. Cell Death Differ. 2023, 30(7): 1695-1709. (IF: 12.4)
2) Zhan M, Ding Y, Huang S, Liu Y, Xiao J, Yu H (共同通讯), Lu L and Wang X. Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase. Nature Communication. 2023 May 30;14(1):3123. (IF: 16.6)
3) Yu H（第一作者）, Shi T, Yao L, Xu D, Ding Y, Xia Q, Liu W and Wang X. Elevated nuclear PIGL disrupts the cMyc/BRD4 axis and improves PD-1 blockade therapy by dampening tumour immune evasion. Cellular and Molecular Immunology. 2023 Jun;20(8):867–880. (IF: 24.1)
4) Yu H（第一作者）, He J, Liu W, Feng S, Gao L, Xu Y, Zhang Y, Hou X, Zhou Y, Yang L, Wang X. The Transcriptional Coactivator, ALL1-Fused Gene from Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer. Hepatology. 2021 Oct;74(4):1952-1970. (IF: 17.4)
5) Yu H（第一作者）, Ding J, Zhu H, Jing Y, Zhou H, Tian H, Tang K, Wang G, Wang X. LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death Differ. 2020 Nov;27(11):3021-3036. (IF: 10.7)
6)Zhu W, Chu H, Zhang Y, Luo T, Yu H（共同一作）, Zhu H, Liu Y, Gao H, Zhao Y, Li Q, Wang X, Li G, Yang W. Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis. Cell Research. 2023 Mar;33(3):245-257. doi: 10.1038/s41422-022-00773-0. (IF: 44.1)
7)Shao J, Shi T, Yu H（共同一作）, Ding Y, Li L, Wang X, Wang X. Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation. EMBO J. 2021 Oct 18;40(20): e107480. (IF: 11.6)
8)Hu K, Ding Y, Jing X, Zhu H, He W, Yu H (共同通讯) and Wang X. Glutamate dehydrogenase1 supports HIF1α stability to promote colorectal tumorigenesis under hypoxia. EMBO J. 2023 Apr 24: e112675. (IF: 11.4)
9)Zhang Y, Yu H（共同一作）, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X, Li X, Li D, Yang W. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest. 2021 Nov 1;131(21): e146187. (IF: 14.8)
10) Qi D*, Song X, Xue C, Yao W, Shen P, Yu H (共同通讯)*, Zhang Z*. AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis. Cancer Letters. 2021 522(12): 105-118.
11) Tian X, Yu H（共同一作）, Li D, Jin G, Dai S, Gong P, Kong C, Wang X. The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer. Mol Ther. 2021 Mar 3;29(3):1239-1257. (IF: 11.5)
12) Yu K, Ding Y, Yu H（共同一作）, Zhu W, Yu H, Luo Y, Zheng X, Huang Y, Lu Z, Wang X. Visualizing Lysosomal Positioning with a Fluorescent Probe Reveals a New Synergistic Anticancer Effect. ACS Sens. 2022 Jul 22;7(7):1867-1873. doi: 10.1021/acssensors.2c00375. (IF: 9.6)
13)Peng Y, Yu H（共同一作）, Hao X, Dong W, Yin X, Lin M, Zheng J, Zhou B. Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty. EMBO J. 2018, 37(17): 0-e98984. (IF: 11.4)
14) Wang X, Liu R, Zhu W, Chu H, Yu H（第二作者）, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G, Yang W. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019 Jul;571 (7763):127-131. (IF: 43.1)
15) Wang X, Liu R, Qu X, Yu H（第二作者）, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G*, Yang W*. α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development. Molecular Cell, 2019, 76(1): 148-162.e7. (IF: 16.97)
5.联系方式：yuhua@gzhu.edu.cn
